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S H Ralston Selected Research

HCT1027

9/2004The flurbiprofen derivatives HCT1026 and HCT1027 inhibit bone resorption by a mechanism independent of COX inhibition and nitric oxide production.

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S H Ralston Research Topics

Disease

12Osteoporosis
10/2021 - 08/2000
6Bone Resorption
09/2004 - 07/2000
5Inflammation (Inflammations)
05/2017 - 07/2001
4Osteitis Deformans (Paget's Disease of Bone)
11/2006 - 03/2001
4Osteoporotic Fractures
08/2001 - 01/2000
3Bone Diseases (Bone Disease)
03/2012 - 07/2001
3Rheumatoid Arthritis
09/2001 - 07/2000
2Osteoarthritis
09/2015 - 08/2004
2Neoplasms (Cancer)
03/2012 - 12/2002
2Pain (Aches)
01/2007 - 08/2004
2Osteopetrosis
01/2004 - 01/2004
2Metabolic Bone Diseases (Osteopenia)
03/2002 - 08/2000
2hereditary expansile Polyostotic osteolytic dysplasia
11/2001 - 01/2000
1COVID-19
05/2022
1Necrosis
05/2022
1Fatigue
05/2017
1Breast Neoplasms (Breast Cancer)
03/2012
1Osteolysis
03/2012
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2008
1Nerve Compression Syndromes (Nerve Entrapment)
08/2004
1Type 2 Diabetes Mellitus (MODY)
03/2004
1Pre-Eclampsia (Preeclampsia)
12/2002
1Renal Insufficiency (Renal Failure)
12/2002
1Developmental Bone Diseases (Bone Dysplasia)
11/2001
1Colles' Fracture
11/2001
1Osteosarcoma (Osteogenic Sarcoma)
03/2001
1Cerebral Cortical Thinning
02/2001

Drug/Important Bio-Agent (IBA)

5Diphosphonates (Bisphosphonates)IBA
01/2007 - 08/2000
3GlucocorticoidsIBA
05/2022 - 01/2012
3ProstaglandinsIBA
03/2012 - 07/2001
3UbiquitinIBA
11/2006 - 11/2004
3CytokinesIBA
12/2001 - 07/2000
3Collagen Type I (Type I Collagen)IBA
08/2001 - 01/2000
2Biomarkers (Surrogate Marker)IBA
05/2017 - 10/2014
2Calcitriol Receptors (Calcitriol Receptor)IBA
04/2008 - 08/2000
2Proteins (Proteins, Gene)FDA Link
11/2006 - 08/2000
2nitroflurbiprofenIBA
09/2004 - 09/2001
2Bone Density Conservation AgentsIBA
09/2004 - 08/2000
2Flurbiprofen (Froben)FDA LinkGeneric
09/2004 - 09/2001
2Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2004 - 12/2001
2Calcitonin (Calcitonin, Eel)FDA LinkGeneric
08/2004 - 11/2001
2Etidronic Acid (HEDP)FDA LinkGeneric
08/2004 - 03/2002
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
12/2001 - 07/2000
2Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA
11/2001 - 03/2001
2Interleukin-1 (Interleukin 1)IBA
07/2001 - 07/2000
1Methotrexate (Mexate)FDA LinkGeneric
05/2022
1Antirheumatic Agents (DMARD)IBA
05/2022
1Tumor Necrosis Factor InhibitorsIBA
05/2022
1Biological ProductsIBA
05/2022
1Prednisolone (Predate)FDA LinkGeneric
05/2022
1LigandsIBA
09/2015
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
09/2015
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
03/2012
12- ((2,6- dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl esterIBA
03/2012
12-((2,6-dichlorophenyl)amino) benzeneacetic acid 4-(3-thioxo-3H-1,2-dithiol-5-yl) phenyl esterIBA
03/2012
1(3- (2,6- dichloro- phenylamino)phenyl)acetic acid 2-methanesulphonylsulphanyl ethyl esterIBA
03/2012
1Diclofenac (SR 38)FDA LinkGeneric
03/2012
1HydrogenIBA
03/2012
1Genetic Markers (Genetic Marker)IBA
03/2011
1Alkaline PhosphataseIBA
01/2007
1Carrier Proteins (Binding Protein)IBA
11/2006
1InterleukinsIBA
09/2004
1HCT1027IBA
09/2004
1Alendronate (Alendronate Sodium)FDA LinkGeneric
08/2004
1Risedronic Acid (Actonel)FDA LinkGeneric
08/2004
1tiludronic acid (tiludronate)FDA Link
08/2004
1Anti-Inflammatory Agents (Anti-Inflammatories)IBA
08/2004
1Analgesics (Analgesic Drugs)IBA
08/2004
1PPAR gammaIBA
03/2004
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
03/2004
1Chloride Channels (Chloride Channel)IBA
01/2004
1beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA
01/2004
1Proton Pumps (Proton Pump)IBA
01/2004
1Parathyroid Hormone-Related ProteinIBA
12/2002
1Indicators and Reagents (Reagents)IBA
12/2002
1Nitric Oxide Synthase (NO Synthase)IBA
12/2001
1Vitamin DFDA LinkGeneric
11/2001
1CalciumIBA
11/2001
1Arginine (L-Arginine)FDA Link
07/2001
1Protein Isoforms (Isoforms)IBA
07/2001
1DNA (Deoxyribonucleic Acid)IBA
03/2001
1MineralsIBA
02/2001
1Estrogen ReceptorsIBA
01/2001
1TransferasesIBA
08/2000
1NitrogenIBA
08/2000
1CollagenIBA
08/2000
1GGTI 298IBA
08/2000
1FTI 277IBA
08/2000
1Parathyroid Hormone (Parathormone)IBA
07/2000
1Hormones (Hormone)IBA
07/2000
1Calcitriol (Calcijex)FDA LinkGeneric
07/2000
1Protein Sorting Signals (Signal Peptide)IBA
01/2000

Therapy/Procedure

5Therapeutics
09/2012 - 08/2000
1Ambulatory Care (Outpatient Care)
10/2021
1Secondary Prevention
11/2001
1Ovariectomy (Oophorectomy)
09/2001